Pathophysiology and Evolving Treatment Options of Septic Arthritis: A Narrative Review

Abstract

Pyogenic (septic) arthritis is a severe joint infection characterized by the invasion of microorganisms into the synovium, causing inflammation and joint destruction. This review article provides a comprehensive overview of pyogenic arthritis, focusing on etiology, pathogenesis, clinical manifestations, diagnosis, and management strategies. This review explores routes of microbial entry into joints, emphasizing the importance of prompt identification and treatment to prevent irreversible joint damage. Clinical manifestations, such as joint pain, swelling, and limited range of motion, are discussed, along with the challenges in differentiating pyogenic arthritis from other joint disorders. Diagnostic approaches, including joint aspiration and imaging modalities, are critically examined for accuracy in confirming diagnosis. This review also addresses the significance of early intervention through antimicrobial therapy and joint drainage, highlighting the role of multidisciplinary collaboration in optimizing patient outcomes. In summary, the present investigation underscores the complexities of pyogenic arthritis and the need for a comprehensive understanding of pathophysiology for timely and effective management to improve patient prognosis and quality of life.

 

Alan D. Kaye, Driskell Greene, Alana V Alvarez-Amado, Horace L. Townsend, Michael Forte, Megan Vasterling, Jon D. Hirsch, Jeffrey Howard, Shahab Ahmadzadeh, Olga Willett, Adam M. Kaye, Sahar Shekoohi, Giustino Varrassi (July 31, 2024) Pathophysiology and Evolving Treatment Options of Septic Arthritis: A Narrative Review. Cureus 16(7): e65883. doi:10.7759/cureus.65883